A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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‘Of course, that is about appropriate. I search for a Bodily comprehension of Organic techniques in a very bottom-up way. I believe you could possibly distinguish three lines of investigation in my team in the mean time. The initial problems chromosome structure: How can you get yourself a metre-extensive DNA polymer folded and organised in such a microscopic cell? We've got formulated visualisation techniques that permit us to review how, one example is, SMC proteins loop DNA (online video on Youtube) to be able to Construct up chromosomes.
Our group research bacterial cell division and is particularly aiming to represent a ‘base up biology’ in synthetic cells that may autonomously divide. Our main desire lies in mobile division, chromatin construction, and spatial control.
, Groningen researchers present the outcomes of their attempts to generate labs far more sustainable and supply tricks for other labs.
2007, first actual-time detection of strand Trade in homologous recombination by RecA; discovery of the reduced persistence size of finishes of microtubules; and resolved the mechanism of biosensing with carbon nanotubes
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Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
You're a Christian. If you can make this kind of synthetic mobile, would you be a single move https://www.ceesdekker.net closer to God, or would the role of God have diminished considerably once more?
Stream-pushed rotary motors such as windmills and water wheels generate useful procedures in human Modern society. Although examples of this kind of rotary motors also attribute prominently in mobile biology, their artificial design within the nanoscale has remained complicated. Right here we display move-driven rotary motion of the self-organized DNA nanostructure that is certainly docked on to a nanopore in a skinny good-point out membrane. An elastic DNA bundle self-assembles into a chiral conformation upon phoretic docking on to the stable-state nanopore, and subsequently displays a sustained unidirectional rotary movement of up to 20 rev s−1.
The rotors harness Electricity from a nanoscale drinking water and ion flow that is definitely generated by a static chemical or electrochemical likely gradient in the nanopore, that happen to be established by way of a salt gradient or used voltage, respectively. These synthetic nanoengines self-organize and run autonomously in physiological conditions, suggesting strategies to developing Power-transducing motors at nanoscale interfaces.
It absolutely was throughout this period that Dekker completed investigation on magnetic spin devices and on sounds in superconductors and semiconductors.
An built-in microfluidic System for quantifying drug permeation across biomimetic vesicle membranes
‘That concerns the synthetic mobile, as A part of the Dutch BaSyC initiative. Craig Venter appeared leading-down in All those days and recognized about 5 hundred genes which are minimally essential for a working mobile. We wish to appear base-up: how can we move from a number of molecules to an entire biological program?
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
Good-point out nanopores have tested to be a surprisingly versatile probe for single-molecule analysis of DNA. I will describe some of our recent conclusions – specifically DNA knots – as well as our endeavours to extend the abilities of stable-condition nanopores even even more, while in the route of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.